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Certain toxins and drug overdoses can be removed via extracorporeal therapy
Molecules <40KDa
Protein binding <80%
Ethylene glycol
Methanol
Ethanol
Phenobarbital
Caffeine
Lithium
Salicylates
Betablockers
Theophyline
Meprobamate
Metformin
Cyclophosphamide
Baclofen
Molecular weight <40KDa
Volume of distribution > 0.5L/kg
Protein binding >80%
Enrofloxacin
Amatoxins
Amitriptyline
Vincristine
Ibuprofen
Therapeutic plasma exchange
Molecular weight >40KDa
Protein binding >80%
Volume of distribution < 0.5 L/Kg
PB<80%+MW>40KDa+Vd <1 L/Kg
Detemir insulin
Envenemation
Ibuprofen
Mushroom
Onsior
Vincristine
Hemoperfusion
Hemodialysis & hemodiafiltration
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